Abstract
The clinical course of age-related macular degeneration (AMD) is related to choroidal conditions, and can be determined by the evaluation of the central choroidal thickness (CCT). The aim of this study was to determine the association between the axial length (AL) and choroidal thickness in AMD by measuring these parameters in patients with and without AMD. Seventy eyes of 70 patients (34 men and 36 women; age, 64–88 years; mean age, 77.0 ± 6.5 years) who underwent cataract surgery from February 2015 to March 2020 at the Department of Ophthalmology, Keio University School of Medicine were retrospectively analyzed. The AMD group (29 patients, 29 eyes) included eyes with early AMD, whereas the control group (41 patients, 41 eyes) included those without ocular diseases other than cataract. Optical coherence tomography images were used to measure the CCT and the choroidal vessel diameter (CVD). The IOL Master was used to measure the AL. The results revealed that mean CCT was greater in the AMD group (238.3 ± 108.3 μm) compared with the age-matched control group (187.2 ± 66.8 μm) (p = 0.03). The CCT was negatively correlated with AL in the overall sample (r = -0.42, p = 0.001), the AMD group (r = -0.42, p = 0.02), and the control group (r = -0.42, p = 0.006). Note that all eyes with CCT > 350 μm were included in the AMD group. CCT and CVD were positively correlated in the overall sample (r = 0.76, p < 0.001) as well as in the individual groups (AMD: r = 0.82, p < 0.001; control: r = 0.76, p = 0.004). Given that CCT is an important parameter for predicting the prognosis of subfoveal diseases, routine evaluation of AL may be valuable for a better understanding of the pathogenesis of AMD.
Highlights
The mean central choroidal thickness (CCT) was significantly greater in the age-related macular degeneration (AMD) group (238.3 ± 108.3 μm) compared with the control group (187.2 ± 66.8 μm) (p = 0.03, Table 1), and mean choroidal vessel diameter (CVD) had a similar trend (AMD vs control, 124.1 ± 71.8 μm vs 96.5 ± 41.3 μm; p = 0.07, Table 1)
CCT was negatively correlated with axial length (AL) in overall group; this finding was observed when patients with AMD and control were separately analyzed
The eyes with CCT >350 μm were all in the AMD group
Summary
Due to recent progress in medical science, anti-vascular endothelial growth factor (antiVEGF) therapy has been developed for the treatment of age-related macular degeneration. Axial length and choroidal thickness in early AMD (AMD). AMD is still one of the major causes of blindness in the elderly people, worldwide [1]. In AMD, the lesion spreads from the choroid to the retina, and the choroidal condition may affect the prognosis [2]. Choroidal research has been attracting attention in the field [2,3,4,5,6]. Determinants of choroidal condition (such as the thickness), in elderly patients who may be affected with AMD in particular, are not fully understood
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.