Abstract
The study aimed to analyze the scientific production on the association between asthma and type 2 diabetes mellitus (T2DM) in adults, the mechanisms that explain this association, and its impact on asthma control. A literature review of scientific articles indexed in the MEDLINE/PUBMED, BVS, CINAHL, Cochrane Library, and Web of Science databases was carried out, considering publications from January 2009 to December 2019, using the following descriptors: “asthma”, “type 2 diabetes”, “adult,” and “association”. Of 962 articles found, 18 were included because they met the eligibility criteria. It is suggested that the association between asthma and T2DM is caused by low-grade systemic inflammation (7 articles) or the use of corticosteroids (7 articles). It is noticed that there is a limited scientific production regarding the consequences of this association for the control of asthma (5 articles). It is concluded that asthma and T2DM are two common chronic conditions of increasing prevalence and that often coexist in the same patient. It is suggested that this coexistence worsens asthma control. Therefore, the study may support public policies and clinical health practices that value the approach of comorbidities associated with asthma such as T2DM, in order to minimize additional health risks and reduce the quality of life.
Highlights
Asthma is a heterogeneous disease, characterized by chronic inflammation and airway hyperresponsiveness [1]
Asthma has been associated with an increased risk of Type 2 diabetes mellitus (T2DM) in women, regardless of body mass index (BMI), indicating that chronic inflammation contributes to the pathogenesis of diabetes [15]. e role of adiposity in Canadian Respiratory Journal pathogenic pathways linking asthma and T2DM needs to be further studied [16, 17]
It is important to note that the various plausible mechanisms for the increased risk of T2DM among asthmatics can be altered or aggravated by the asthma phenotype [14]. Taking these aspects into consideration, this study aims to analyze the scientific production on the association between asthma and T2DM, the mechanisms that explain this association, and its impact on asthma control. is theme is relevant, as it may contribute to the development of public policies and clinical practices that guarantee the improvement of care for people with coexisting chronic conditions such as asthma and T2DM, aiming at a comprehensive approach at all healthcare levels for these individuals, as well as better quality of life and lower costs
Summary
Asthma is a heterogeneous disease, characterized by chronic inflammation and airway hyperresponsiveness [1]. Type 2 diabetes mellitus (T2DM) is a multifactorial disease, mainly characterized by a decrease in insulin sensitivity and by a defect in insulin secretion and chronic inflammation [2]. Obesity, and T2DM are very common chronic health conditions [5, 8]. Obesity seems to be an important contributor to the association asthma and T2DM, but the mechanism linking those three chronic conditions is poorly understood [3, 5]. Asthma has been associated with an increased risk of T2DM in women, regardless of body mass index (BMI), indicating that chronic inflammation contributes to the pathogenesis of diabetes [15]. Asthma has been associated with an increased risk of T2DM in women, regardless of body mass index (BMI), indicating that chronic inflammation contributes to the pathogenesis of diabetes [15]. e role of adiposity in Canadian Respiratory Journal pathogenic pathways linking asthma and T2DM needs to be further studied [16, 17]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call