Abstract
A study from Thailand showed no significant association between the adiponectin (ADIPOQ) gene rs1501299 polymorphism and knee osteoarthritis (OA) risk. To investigate this association in a Chinese population, we conducted this case–control study involving 372 knee OA patients and 453 controls. Genotyping via standard PCR and restriction fragment length polymorphism (PCR-RFLP) showed that TT genotype (TT vs. GG: adjusted odds ratio (OR) (95% confidence interval (CI)) = 1.70 (1.01–2.86)) or T allele (T vs. G: adjusted OR (95% CI) = 1.26 (1.02–1.56)) of ADIPOQ gene rs1501299 polymorphism significantly increased the risk of knee OA. Significant associations were also observed in subgroups ≥55 years (TT vs. GG: adjusted OR (95% CI) = 2.21 (1.00–4.86)) and body mass index (BMI) < 25 kg/m2 (TT+GT vs. GG: adjusted OR (95% CI) = 1.53 (1.03–2.29)), but not in the subgroup analysis of sex. In conclusion, the ADIPOQ gene rs1501299 polymorphism intensifies the risk of knee OA in this Chinese Han population. Nevertheless, further studies with larger sample sizes in other populations are warranted to verify this finding.
Highlights
Osteoarthritis (OA) is a clinical syndrome of joint pain and dysfunction that attacks millions of people [1]
Excessive body mass index (BMI), joint surgery, and trauma that are recognized as the causes of OA, genome-wide association studies show genetic factors contribute to OA development [9,10,11]
Logistic regression analyses showed TT genotype of this polymorphism significantly increased the risk of knee OA (TT vs. GG: adjusted odds ratio (OR) and 95% confidence interval (CI), 1.70 (1.01–2.89), P=0.046) (Table 2)
Summary
Osteoarthritis (OA) is a clinical syndrome of joint pain and dysfunction that attacks millions of people [1]. Sex, body mass index (BMI), and repetitive joint activity are all involved in OA development [7,8]. Excessive BMI, joint surgery, and trauma that are recognized as the causes of OA, genome-wide association studies show genetic factors contribute to OA development [9,10,11]. Several studies have explored the association between ADIPOQ gene polymorphisms and OA risk [26,27,28], but present contradictory and inconclusive findings. This case–control study was conducted to verify such relationship in a Chinese Han population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
