Abstract
Purpose: Diffusion tensor magnetic resonance imaging (DT-MRI) has the ability to gather information on tissue microstructure by using the indices that quantify the anisotropy of water diffusion in tissues. This study was designed to find out the impact of patient clinical disability on diffusion tensor (DT) indices. Method: In this paper, images were generated from the data acquired at 3T among 25 MS patients (mean age [Formula: see text] years old). DT indices including fractional anisotropy (FA), mean diffusivity (MD), relative anisotropy (RA), and volume ratio (VR) of multiple sclerosis (MS) lesions are calculated and the correlation between Kurtzke expanded disability status scale (EDSS) score and the values of DT indices of 25 MS patients lesions are obtained. The correlation comparison procedure is done between the EDSS scores and DT indices in MS lesions attained, respectively, from fluid attenuated inversion recovery (FLAIR) images and black holes of T1-weighted (T1-w) images. Results: EDSS scores and DT indices of MS lesions extracted from the black holes present in T1-w images are more correlated in comparison with those extracted from FLAIR images. It is found that MD has a significant correlation with EDSS in both types of images. The results of FLAIR image processing indicates that any increase in EDSS leads to decreasing FA and RA on one hand and increasing MD and VR on the other hand. The correlation between the identical size of lesions in different parts of brain with EDSS shows that the location of lesion in brain also has a correlation with EDSS. Conclusion: The results showed, MD is the best biomarker of clinical disability between these four DT indices. It is also concluded that the correlation between DT indices of frontal brain lesions and EDSS is higher than the other selected brain parts.
Published Version
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