Abstract
Objective To investigate the relationship between testosterone, dehydroepiandrosterone (DEHA) and cholelithiasis among women in climacteric transition period. Methods A total of 2 127 women aged 40~55 were included from the Study of Women's Health Across the Nation. Individuals were divided into gallstone group (n=129) and control group (n=1 998). Serum testosterone, DEHA and other clinical indicators were measured. Mann-Whitney U test was used to compare the averages of continuous variables between groups. Logistic regression was used to analyse the associations between testosterone and DEHA and cholelithiasis. Results The gallstone group had higher testosterone, systolic blood pressure, BMI, waist circumference, hip circumference, triglyceride, C-reactive protein, and lower DHEA, sex hormone binding globulin and high density lipoprotein (P<0.05). After fully adjusting the covariates, testosterone and DEHA levels were correlated with gallstone occurrence, OR (95% CI) were 1.010(1.005~1.015) and 0.994 (0.991~0.997), respectively. In multivariate logistic regression, testosterone may be independent risk factors for gallstones, OR (95% CI) were 1.012(1.007~1.016). DEHA may be independent protective factors for the end of gallbladder, OR (95%CI) were 0.994 (0.991~0.997). Conclusion Testosterone was positively correlated with gallstone risk and DEHA was negatively correlated with gallstone risk in transitional menopausal women. Key words: Testosterone; Dehydroepiandrosterone; Cholelithiasis; Menopause; Causality
Published Version
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