Assignment of the gene coding for the α2-macroglobulin receptor to mouse chromosome 15 and to human chromosome 12q13–q14 by isotopic and nonisotopic in situ hybridization

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The assignment of the gene encoding the α 2-macroglobulin receptor (A2MR), which was first described as the low-density lipoprotein receptor-related protein, was confirmed by nonisotopic and isotopic in situ hybridizations on normal human metaphases to the region 12q13–q14. The same human cDNA, which has 95% sequence identity with the mouse A2mr, was hybridized to metaphases containing the Robertsonian translocation Rb(6;15) 1Ald. The mouse A2mr gene was assigned to chromosome 15 in the region B2-D1. this locus and other loci on mouse chromosome 15 have been shown to be homologous with loci on human chromosome 12q.