Assessment of wound healing potential in mice of formulations prepared from methanolic extract of Oxalis corniculata L. and Hypericum oblongifolium Choisy of Uttarakhand

Abstract

The skin develops a wound that is both anatomical and functional. Wound healing is a difficult process of tissue remodeling or repair following injury. In the past, various types of wounds have been treated and managed using plants and chemical components derived from plants. Various varieties are now being explored to establish an affordable, reliable and efficient delivery system for the treatment of wounds. This study used a mouse model to investigate the effects of Methanolic leaf extracts of Oxalis corniculata and Hypericum oblongifolium on wound healing. Oxalis corniculata L. and Hypericum oblongifolium Choisy plant leaf that had been dried by the air was ground up, extracted with methanol and made into formulation code gel F4, F6 and F8. The above formulations were then put topically to test their ability to speed up the healing of excision wound models. The wound contraction, epithelialization time and tensile strength were all measured. Increases in percentage wound contraction and tensile strength, as well as a reduction in the time needed for epithelialization, were seen with both F6 and F8 extract gel formulations. The results of this study correlated the Oxalis corniculata L. and Hypericum oblongifolium Choisy use of the plants by demonstrating that their leaf extracts had strong wound healing efficacy.