Assessment of Traffic Policemen Exposure To Benzene by Using Trans, Trans-Muconic Acid Biomarker in Ahvaz City, Iran

Neisi Abdolkazem,Behroozi Hamid,Mahmoudi Parviz,Kayedi Neda,Jiaqing Hao

doi:10.14302/issn.2572-3030.jcgb-20-3407

Abstract

Benzene is known as an environmental and industrial pollutant. One way to check the amount of exposure to benzene is to measure its metabolites in the urine. Trans, Trans-Muconic Acid which is one of its metabolites is also as a biological indicator of exposure to benzene. In this study, the relationship between the amount of this biomarker and the environmental benzene concentration was investigated in two groups of policemen working outdoors in the traffic-congested areas and indoor in the same area. The results showed that the highest amount of benzene was in Salman Farsi Station at 4.44 ppm. At the same time, the biomarker measured in the urine showed 127.20 μg / L, which was the highest amount. In addition, the amount of benzene in the outdoor was approximately 3 times more than indoor and the amount of biomarker measured in outdoor employees was two times more than indoors ones. In general, wherever there was more benzene, the biomarker would also show a higher amount.

Highlights

Benzene is a volatile aromatic hydrocarbon that is widely distributed as a natural compound in petroleum, and it spreads through incomplete combustion in motor vehicles
This compound is converted into several compounds by enzymes and non-enzymes pathways, which can be converted to phenol (74-87%) or intermixed with glutathione (1%) and converted to the form of s-phenyl mercapturic acid (SPMA)
The validity of using trans, trans muconic acid was confirmed for the biological monitoring of exposure to low-benzene concentrations [7]

Summary

Introduction

Benzene is a volatile aromatic hydrocarbon that is widely distributed as a natural compound in petroleum, and it spreads through incomplete combustion in motor vehicles. Benzene is converted into benzene oxide by cytochrome enzyme in the liver. This compound is converted into several compounds by enzymes and non-enzymes pathways, which can be converted to phenol (74-87%) or intermixed with glutathione (1%) and converted to the form of s-phenyl mercapturic acid (SPMA). It can be converted to Trans, trans-muconaldyde, and to Trans muconic acid through the opening of the ring (2%). The American Conference of Governmental Industrial Hygienists (ACGIH) has suggested the use of SPMA and t, t-MA as a biomarker for exposure to benzene [1]

Methods

Results

Conclusion