Abstract
Background: Cardiovascular diseases are the leading cause of death in developed countries. In Egypt mortality rates from coronary heart disease are one of the highest worldwide, also coronary heart diseases will be the leading cause of death in developing countries by the year 2020. P2Y12 ADP receptor gene polymorphism is now considered one important implication factor in atherothrombosis and coronary heart diseases. Aim: To assess the correlation between the platelet Adenosine Diphosphate receptor (P2Y12) polymorphism and coronary heart disease patients in Ismailia. Subject and Methods: An analytical case-control study; conducted on 100 volunteers divided into 2 groups; 50 for study (patient) group and 50 for the control group at Ismailia Hospitals' Cardiology premises (clinics & inpatient department) to assess the correlation between the platelet ADP receptor (P2Y12) polymorphism and coronary heart diseases in Ismailia. The patients were subjected to an Interview Questionnaire, clinical examination, and Laboratory Investigations and testing for P2Y12 gene polymorphism. Results: In the study group, 42% of patients were hypertensive, 48% were diabetics, 60% were dyslipidemic and 66% were smokers. In the control group individuals, 26% were hypertensive, 20% were diabetics, 12% were dyslipidemic and 24% were smokers. DNA extraction and examination for P2Y12 gene polymorphism were negative in all participants. Conclusion: Our study revealed that there is no correlation between the platelet ADP receptor (P2Y12) gene polymorphism and coronary heart diseases in Ismailia. Keywords: Ischemic heart disease, Thrombophilia, Platelet glycoproteins, Atherothrombosis
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