Abstract
Medicinal plants are widely used in disease management all over the world. Plant-based traditional medicines are still of great importance to people living in developing countries and also serve as a source to discover new drugs for a variety of diseases affecting man. The aim of this study is to investigate the effect of garlic-citrus-tumeric shot on bilirubin, ALP, ALT and AST of adult albino wistar rats. The animals were divided into two groups; the control group and the experimental animals. A total of five (5) adult wistar rats were used for the control group, while fifteen (15) adult wistar rats were used for the experimental studies. During the period of acclimatization, the rats were fed growers’ mash water provided ad libitum. At every stage of the weight determinations, the test groups (B, C and D) presented body weight reductions. Body weights were found to be significantly increased in the control and tests groups before and after acclimatization. However, variations in body reductions were observed between the control and test rats. Comparatively, these body weight variations were significant in group C (175.00±0.01 g) and D (171.67±24.83 g) after garlic-citrus-tumeric shot administration. The results showed that AST levels were significantly lower (p<0.05) in rats (23.73±7.93 U/L) when compared with the control (33.60±6.23 U/L). Also, ALT levels were significantly lower (p<0.05) in rats (19.67±7.58 U/L) when compared with the control (28.40±5.18 U/L). ALP levels were also lower (p<0.05) in rats (17.13±5.36 U/L) when compared with the control (24.80±4.15 U/L). Furthermore, TB levels were also significantly lower (p<0.05) in rats (0.38±0.14 mg/dl) when compared with the control (0.80±0.16 mg/dl). Also, CB levels were significantly lower (p<0.05) in rats (0.21±0.11 mg/dl) when compared with the control (0.38±0.08 mg/dl). Garlic-citrus-tumeric shot inhibits elevations of biochemical markers of hepatic and renal functions. This suggests that combination of garlic-citrus-tumeric shot is not toxic to the liver. Conclusively, the increase in extract given to adult wister rat decreases the parameters of liver function test thereby increases liver normalcy or better the performance state of the liver, hence, when the extract is taking in the right proportion increases the performance of the liver.
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