Assessment of the Effectiveness of Gemcitabine, Metformin, Citrus Pectin and Their Combinations on the Growth of Transgrant Walker Carcinosarcoma

Abstract

One of the important problems of modern society is the prevention and treatment of cancer. To increase the effectiveness of existing methods, it is promising to use biological response modifiers, the combination of which with traditional methods makes it possible to increase the effectiveness of therapy. The article presents the results of experiments studying the combined effects of metformin, low molecular weight pectin and the cytostatic drug gemcitabine on a transplantable tumor — Walker carcinosarcoma 256. The experimental results demonstrated a clear effect of reducing the toxicity of gemcitabine when administered in high doses in combination with pectasol and metformin. It has been shown that with combined therapy, the rates of inhibition of tumor growth and increase in life expectancy are higher than with monotherapy.