Abstract
Introduction: Hand-wrist radiography have been the method of choice for assessment of skeletal maturity. However, additional radiographic exposure and subjectivity of staging makes the use of hand-wrist radiographs questionable. Insulin-like Growth factor 1 (IGF-1) is a circulating growth hormone dependent factor whose levels correlate with growth spurt. Study evaluates use of IGF-1 levels as skeletal maturity indicator. Aims and objectives: To compare mean IGF-1 levels at different stages of skeletal maturity using hand wrist radios and to assess whether serum IGF-1 levels can be used as skeletal maturity indicator. Materials and methods: Hand-wrist radiographs and blood samples of 45 subjects were collected. Staging of hand-wrist radiographs was done according to Bjork, Grave and Brown method. The IGF-1 serum levels in different stages of skeletal maturity were compared. Results: ANOVA and post hoc Tukey test showed that IGF-1 levels at pubertal stage were significantly higher than the prepubertal and postpubertal phases. Conclusion: IGF-1 levels were significantly higher in pubertal stage as compared to prepubertal and postpubertal stages. IGF-1 levels might prove to be a valuable skeletal maturity indicator.
Published Version
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