Abstract
Serum cholinesterase levels are closely correlated with the severity of liver disease. The aim of the paper was to assess the value of serum cholinesterase in evaluating liver reserve function in cirrhotic patients. 90 patients with liver cirrhosis and thirty healthy control group were included. Liver cirrhosis patients were classified according to child score into three equal groups: Child A liver cirrhosis, Child B liver cirrhosis and Child C liver cirrhosis. Patients were subjected to clinical evaluation, laboratory analysis, abdominal U/S. Measuring serum cholinesterase, and Calculation of both Child and model of end stage liver disease (MELD) scores. The level of serum cholinesterase was higher in control group than the three groups of liver cirrhosis with median (IQR) 17,410 (12,111-21,774), 7528 (5200-9856), 6021 (4500-7542), 3828.5 (1541-6060), respectively P<0.001). And the level of serum cholinesterase was higher in Child A more than Child B and Child C and the level of serum cholinesterase was higher in Child B more than Child C with very strong negative correlation between serum Cholinesterase level and Child score (r=-0.9, P<0.001). Also strong negative correlation between serum Cholinesterase level and MELD score (r=- 0.85, P=0.001), and positive correlation with prothrombin concentration (r=0.554, P=0.009), and serum albumin levels (r=0.582, P=0.0002). Serum cholinesterase is a good biomarker of cirrhosis. Since it distinguishes decompensated from compensated cirrhosis well, low levels in cirrhosis may serve as a useful prognostic marker of advanced liver disease.
Highlights
Cholinesterase has a serum half-life we prospectively enrolled 30 sex and age between 8 and 12 days, and is an alpha 2 matched normal healthy persons and 90 globulin, a tetramer of 342,000 molecular patients with liver cirrhosis, who wereAccording to the World Health weight, that exists in aggregate form. referred to the outpatient department and [Gastroenterology Insights 2017; 8:6914] [page 1]Article internal medicine hospital at Kasr Al-Ainy clotted blood by centrifugation within 1 h of was statistical significance difference as between December 2014 and May 2015 . sampling
Originally used to predict mortality during surgery, the Child-Pugh score is used to determine the prognosis as well as the required strength of treatment, and the necessity for liver transplantation. The cirrhotic patients, those with Child grades B and C with ascites or hemorrhagic tendency, are ly usually treated with albumin or blood transfusion, which may affect the real numerical n value for calculating the Child-Pugh score. o The model of end stage liver disease (MELD) score was developed to estimate e the risks in patients undergoing (TIPS) pros cedure and to attribute the risk of death for u patients with liver cirrhosis allocated for liver transplantation.[4]
We examined if serum o ChE levels can differentiate decompensated N cirrhosis (DC) from compensated cirrhosis
Summary
Cholinesterase has a serum half-life we prospectively enrolled 30 sex and age between 8 and 12 days, and is an alpha 2 matched normal healthy persons and 90 globulin, a tetramer of 342,000 molecular patients with liver cirrhosis, who were. Serum cholinesterase activity regard history of HCV infection, HBV. Patients with liver cirrhosis were divid- was determined using an assay with infection between control and other three ed according to Child Score into butyrylthiocholine as the substrate. We excluded patients less than 18 years term of mean, standard deviation, and per- bilirubin level (P
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