Abstract
Ethanolic extract of Hygrophila spinosa plant was prepared and tested for its phytochemical and pharmacological investigation. The extract showed the presence of steroid, alkaloid, reducing sugar, tannin,flavonoids, saponin and glycoside. The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (58.8%, P<0.001 and 25% at the dose of 500 and 250 mg/kg body weight respectively) and it is comparable to the activity of the standard analgesic drug diclofenac sodium (72.5%, P<0.001 at the dose of 25 mg/kg body weight). The extract of H. spinosa offered about 1.20 hr and 1.8 hr (P<0.001) of the mean latent period for diarrhoeal episode at the doses of 250 and 500 mg/kg body weight which is comparable to the standard antidiarrhoeal drug loperamide. The results tend to suggest that the plant possess analgesic and antidiarrhoeal activities or active constituent(s) responsible for the mentioned activities and thus supported its traditional uses.
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