Assessment of mixed micellization behavior of amitriptyline hydrochloride and TX-165 surfactant mixture in various media (aqueous/NaCl/urea)

Abstract

Herein, mixed micellization behavior of the antidepressant drug amitriptyline hydrochloride (AMT) + nonionic surfactant triton X-165 (TX-165) mixtures were investigated thoroughly using various techniques. Dullness and depression are treated with AMT. Effect of different media of fixed concentration (aq./50 mmol kg−1 NaCl/500 mmol kg−1 urea) was exposed on the AMT interaction with TX-165 by tensiometry technique at 298.15 K. For AMT + TX-165 mixture, the assessed critical micelles concentration (cmc) was achieved lower compared with calculated ideal cmc value (cmc*) of respective system as a result of the nonideal behavior of mixed system. AMT and TX-165 interaction in aq. NaCl solvent was more pronounced than aqueous solution but was less apparent when using urea solution, i.e., AMT interacted with TX-165 in different solvents as given order: NaCl > aqueous > urea. As a result of TX-165′s higher hydrophobicity, TX-165 accomplished to have a more fraction in mixed micelles compared with AMT.The micellar composition of TX-165 (X1Rub) was attained larger than the corresponding employed mole fraction of TX-165 (α1) with exception at α1 = 0.9. It was found that in all cases, the interaction parameter (βRub) was negative, indicating a synergistic/attractive interaction between AMT and TX-165. Thermodynamic studies have revealed that the formation of mixed micelles of AMT + TX-165 is worthwhile, as well as spontaneous. The Gibb’s free energy (ΔGm°) value of studied system was found negative in each employed solvent showing the spontaneity of system, and spontaneity was highest with NaCl and lowest with urea than in aqueous solution. FT-IR spectra revealed the shifting of wavelength of constituent mixture compared with singular employed constituent, which elucidates the interaction amongst them. The interactions between AMT and TX-165 were revealed on the atomic scale using molecular dynamics simulation, demonstrating good agreement with the results of the experiments. Considering these results, a drug delivery system might be developed.