Abstract
BackgroundThis study evaluates the macular function changes in patients with idiopathic macular epiretinal membrane (ERM) by multifocal electroretinography (mfERG) and their correlations with visual acuity and central macular thickness (CMT) by optical coherence tomography (OCT).MethodsTwenty eyes of 20 patients with ERM underwent OCT and mfERG examinations. The response amplitude densities and implicit times of mfERG were compared to the control fellow eyes. Correlation analyses among visual acuity, central macular thickness and mfERG values in the central two concentric rings were performed.ResultsThe mfERG P1 response amplitude densities in ring 1–2 and P1 implicit time in ring1 were significantly changed in epiretinal membrane eyes compared with controls (P < 0.05). Multivariate stepwise linear regression analyses showed LogMAR visual acuity was significantly correlated with CMT (P = 0.004), and also with the P1 amplitude density in ring 1 (P = 0.002). CMT showed significant correlation with P1 implicit time in ring 2 (P = 0.013).ConclusionsThe mfERG abnormalities show macular function changes and correlate with visual acuity and central macular thickness in eyes with ERM. In first-order mfERG responses, P1 wave changes may be a sensitive functional measurement for ERM patients.
Highlights
This study evaluates the macular function changes in patients with idiopathic macular epiretinal membrane (ERM) by multifocal electroretinography and their correlations with visual acuity and central macular thickness (CMT) by optical coherence tomography (OCT)
The functional and anatomical measurements for ERM are usually based on visual acuity and optical coherence tomography (OCT) [1]
The mean best-corrected visual acuity (BCVA) of affected eyes was 0.39 ± 0.24 logMAR, which was statistically significant compared with the control fellow eyes (t = 4.935, P < 0.05)
Summary
This study evaluates the macular function changes in patients with idiopathic macular epiretinal membrane (ERM) by multifocal electroretinography (mfERG) and their correlations with visual acuity and central macular thickness (CMT) by optical coherence tomography (OCT). The functional and anatomical measurements for ERM are usually based on visual acuity and optical coherence tomography (OCT) [1]. Multifocal electroretinography (mfERG),as a noninvasive, objective method to detect regional functional changes in the central retina by measuring electrophysiologic responses, has demonstrated macular function changes in eyes with ERM by several reports [2,3,4,5,6]. The purpose of the study is to assess first-order mfERG changes in ERM patients and to evaluate the correlations among the visual acuity, OCT parameters and mfERG values
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