Assessment Of Left and Right Ventricular Functions In Overweight and Obese Females by Different Echo-Doppler Modalities

Abstract

Abstract Aim of work Assessment of left and right ventricular functions in overweight and obese females using different echo-Doppler modalities. Methods This study included 32 obese females (group I), 26 overweight females (group II) -both of them have no chronic illnesses- in addition to 25 healthy females (group III) as a control group. All of them had hsCRP level measured. The following parameters were measured using 2D echocardiography: LA, Ao, LA/Ao ratio, LV measures included LV dimensions, 2D LVEF, 2D LV global longitudinal strain (LVGLS), average LV Sm, Em, Am, LV E/Em ratio, LV E, A and LV E/A ratio. RV measures included LV dimensions, RV FAC, RV Tei index, TAPSE, RV Sm, Em, Am, Em/Am ratio, RV E, A, E/A ratio and PASP. Results hsCRP, LA, Ao, LV dimensions, Average LV Am, E/Em, RVD1, RV Tei and PASP were significantly higher in group I compared to group III, but group I had significantly lower LV E/A, LV Sm, Em, LVGLS, RV E/A, Em/Am and RVGLS compared to group III. Group II had significantly higher hsCRP, Ao and RV Tei and significantly lower LV E/A ratio and LV Em compared to group III. On the other hand, group, I had significantly lower average Sm, LVGLS and RVGLS than group II but no significant difference detected between two groups as regard LV and RV diastolic function. Pulse, BMI, BSA, waist circumference, waist to hip ratio, hsCRP were negatively correlated with LVGLS and RVGLS. Cut-off values for BMI showed good sensitivity and specificity to predict impaired LVGLS and RVGLS. Cut-off point 31.9 kg/m2 for impaired LVGLS with sensitivity 80%, specificity 76.81% and p value <0.001, cut-off point >30.73kg/m2 for impaired RVGLS with sensitivity 80%, specificity 69.57% and p value 0.001. Waist circumference was the most sensitive predictor for impaired LVGLS and hsCRP for impaired RVGLS. Conclusion Isolated obesity and overweight are independent predisposing factors for impaired LV and RV systolic and diastolic dysfunctions. TDI and 2D STE are good echo-Doppler modalities to detect subclinical effects on LV and RV functions. Additional Content An author video to accompany this abstract is available on https://academic.oup.com/eurheartjsupp. Please click on the arrow next to ‘More Content’ and then click on ‘Author videos’.