Abstract
Chronic kidney disease (CKD) affects all age groups, and its prevalence has increased during recent years. CKD is divided into six stages, according to the renal function of patients: 1. Normal renal function without kidney damage; 2. Kidney damage with normal renal function; 3. Mild renal insufficiency; 4. Moderate renal insufficiency or lab tests failure; 5. Severe renal insufficiency or clinical failure; 6. End stage of chronic renal failure. This study was intended to assess renal function in elderly patients and identifying the presence of factors associated with those changes. A cross-sectional population-based study was performed. Elderly patients were surveyed between September 2010 and May 2011. Kidney function was assessed by determining of serum creatinine, and estimation of the glomerular filtration rate by the CKD-EPI equation. In all, 822 elderly were surveyed; 61.6% were women; 92.2% were Caucasian; and most (61.0%) were aged between 60 and 69 years. With regard to the glomerular filtration rate, 26.2% had a normal rate; 60.2% showed a slight decrease; 13.0% a moderate decrease; 0.5% severe kidney function decline; and 0.1% extreme fall. Increasing age was associated with kidney damage by decreased glomerular filtration rate (p < 0.001). In addition, obesity, hypertension and smoking were factors independently associated with reduced glomerular filtration rates. This study found that the great majority of the surveyed elderly had some mild kidney damage, and 13.6% showed moderate to severe dysfunction.
Highlights
Chronic kidney disease (CKD) affects all age groups, and its prevalence has increased during recent years
Kidney function was assessed by determining of serum creatinine, and estimation of the glomerular filtration rate by the CKD-EPI equation
This study found that the great majority of the surveyed elderly had some mild kidney damage, and 13.6% showed moderate to severe dysfunction
Summary
Chronic kidney disease (CKD) affects all age groups, and its prevalence has increased during recent years. Kidney function was assessed by determining of serum creatinine, and estimation of the glomerular filtration rate by the CKD-EPI equation. Chronic kidney disease (CKD) affects all age groups and its prevalence has been increasing in recent years and it is, considered a public health problem. Creatinine biological variation is very small, approximately 4%;5 and the analytical variation is below 2% This diagnostic method is quite simple; when within reference values it does not state normal kidney function, because it is a Kidney function in the elderly late parameter of kidney disease.[6] There are formulas developed to estimate glomerular filtration[7] and disease staging[8] based on serum creatinine. The equation used was CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), pointed out by a recent systematic review[9] as one of the most used in medical practice to calculate kidney function
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