Assessment of humoral immunity and health risk to the population living in the area of oil production facilities influence

Abstract

Today, the task of assessing the health risk with the analysis of laboratory studies of the population living in the zone of oil production objects influence, taking into account the real background air pollution, is urgent. Purpose: assessment of public health risk from oil production facilities, taking into account changes in laboratory parameters of humoral immunity of residents. The health risk assessment was carried out under the condition of inhalation consumption of substances by the adult population in accordance with R 2.1.10.1920–04 «Guidelines for assessing the risk to public health when exposed to chemicals that pollute the environment». An adult population living in three villages closest to oil production facilities (1–2 km) was examined, with the determination of the parameters of humoral immunity in the blood serum: (the amount of immunoglobulins IgA, IgM, IgG, IgE) and circulating immune complexes (CIC). The standard values of the indicators were used for conditionally healthy people living in the Orenburg region. It was found that the hazard index calculated for the immune system under background exposure to substances contained in the atmospheric air does not meet hygienic requirements in all studded villages. The maximum levels of the additive risk are established in the settlements closest to the oil production facilities. In the population located in the zone of oil production facilities influence, multidirectional changes in the qualitative and quantitative composition of laboratory parameters of humoral immunity were revealed. A significant increase in IgE immunoglobulins in blood serum, as well as IgA, IgE and CIC, was established in comparison with the indicators standardized for the region.