Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats

Abstract

<p style="text-align: justify;"><strong>Objectives: </strong>To Study the hepatoprotective and antioxidant activity of the whole plant, ethanolic extract of <em>Tephrosia villosa</em> (EETV). <strong>Methods: </strong>Hepatoprotective effect of EETV is studied against carbon tetrachloride (CCl₄) and paracetamol-induced hepatotoxicity in rats. Individual rats received EETV doses of 200 and 400 mg/kg (w/w) for seven days, respectively. On the 7^th day, induced hepatotoxicity in all rats of all groups by 1.25 ml/kg (i.p) CCl₄and paracetamol 1gm/kg/p.o. Determining effects of ETEV on antioxidant activity, SGOT, SGPT, ALP, and direct bilirubin were, and also performed a histopathological exam of the liver sections. Results: The extract prevented the exhaustion of glutathione and catalase levels and increased lipid peroxidation levels against CCl₄ induced and Paracetamol liver injury in rats. By histopathological evidence, EETV also significantly decreased biochemical levels of liver enzymes with high hepatoprotection at 200 mg/kg. <strong>Conclusion: </strong>Present study results strongly reveal that EETV has hepatoprotective and antioxidant activity against CCl₄ and paracetamolinduced hepatic impairment in experimental animals. <p style="text-align: justify;"><strong>Key words: </strong><em>Tephrosia villosa,</em> Hepatoprotective, Antioxidant, Carbon tetrachloride, Paracetamol, Silymarin.