Abstract
The present study was undertaken to investigate hepatoprotective activity of Ficus dalhousiae leaves ethanolic extract based on its traditional claim. Paracetamol- and carbon tetrachloride-induced hepatotoxicity in albino Wistar rats, experimental models was used for the evaluation. Various biochemical parameters like SGPT, SGOT, serum albumin, alkaline phosphatase, total bilirubin, direct bilirubin and total protein were estimated. Oral treatment with the extract 250 and 500 mg/kg, significantly (p<0.01) altered all the serum marker levels to the normal in both the experimental models. The activity of the extract was comparable to that of standard drug, silymarin (25 mg/kg, p.o.). Histopathological observations also demonstrated protective effect of the test extract on liver anatomy. Overall results suggest that F. dalhousiae possesses in vivo hepatoprotective activity.
Highlights
The liver is a vital organ present in vertebrates and in some other animals
In the extract treated group 100 mg/kg there was no effect on ALP, ALB, TB and TP whereas there was slightly significant (p
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Summary
The liver is a vital organ present in vertebrates and in some other animals. It has wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion. Liver has a pivotal role in regulation of physiological processes. It is involved in several vital functions such as metabolism, secretion and storage. The bile secreted by the liver has an important role in digestion. Liver diseases are among the most serious disorders. The liver diseases are mainly caused by toxic chemicals (certain antibiotics, chemotherapeutics, peroxidised oils, aflatoxins, carbon tetrachloride, acetaminophen, chlorinated hydrocarbons, etc.), excess consumption of alcohol, infections and autoimmune disorders
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