Abstract
BackgroundOccupational exposures to hazardous chemicals in paints cause serious health hazards in painters. The present study was designed to evaluate the possibility of hematotoxic and genotoxic effects of paint chemicals among painters in Assiut Governorate, Egypt. In addition the role of oxidative stress and apoptosis in mechanism of such toxic effects were studied.MethodsA case control study was performed on 50 male painters and 50 non-exposed healthy subjects, who were included as a control group after informed consent. Venous blood samples were obtained and analyzed for determination of total and differential blood count as hematotoxic markers as well as serum malondialdehyde (MDA) as an oxidant stress markers and total antioxidant enzymes. In addition, human B-cell lymphoma-2 (Bcl-2), caspase-3 and 8-hydroxyguanosine (8-OHdG) were assayed as markers of apoptosis and genotoxicity.ResultsThere was a statistically significant difference between paint workers and controls as regard total and differential blood count, serum MDA and total anti-oxidant levels. Also, statistical significant differences in caspase-3, Bcl-2 levels and 8-OHdG were observed.ConclusionsChronic occupational exposure to paints increased the risk of hematotoxicity and genotoxicity in painters. Oxidative stress and apoptosis play a major role in such mechanism. Periodic medical examination and application of protective devices is necessary.
Highlights
Paint products contain many chemical compounds like pigments, extenders, binders, additives and solvents
Several studies have investigated whether occupational exposure to paints in general is associated with several adverse health effects such as neurological diseases, hearing loss, renal diseases, skin allergies, hepatic, as well as
Organic solvents in paints and their metabolites are known to be hematotoxic, they are known to have a deleterious effect on bone marrow; these effects may result in a decreased production of red blood cells, white blood cells, and platelets
Summary
Paint products contain many chemical compounds like pigments, extenders, binders, additives and solvents (toluene, xylene, ketones, alcohols, esters, and glycol ethers). Toxicity of these products depends on the types of pigments and solvents used in its manufacture (Scélo et al 2009).Paint solvents are volatile at room temperature. Several studies have investigated whether occupational exposure to paints in general is associated with several adverse health effects such as neurological diseases, hearing loss, renal diseases, skin allergies, hepatic, as well as Organic solvents in paints and their metabolites are known to be hematotoxic, they are known to have a deleterious effect on bone marrow; these effects may result in a decreased production of red blood cells, white blood cells, and platelets. In addition the role of oxidative stress and apoptosis in mechanism of such toxic effects were studied
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