Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a range of hepatic disorders associated with fatty deposits in liver, which occur in the absence of alcohol consumption or alcohol abuse. NAFLD. The present study assessed glutathione level in non-alcoholic fatty liver disease patients. Subjects and Methods: The present study was conducted in Department of Internal Medicine, Narayana Medical College & Hospital, Chintareddy Palem, Nellore, Andhra Pradesh. Duration of the study was from February 2018 to January 2019. 40 patients of NAFLD and 20 cases of fatty liver disease were recruited. Serum levels of 8-OHdG were measured using the highly sensitive 8-OHdG Check enzyme-linked immunosorbent assay (ELISA). Serum levels of GGT were measured using the Qualigent® GGT kit. Serum levels of glutathione (GSH) were measured using the GSH kit. Results: The mean total bilirubin in group I was 1.2 mg/dL and in group II was 0.7 mg/dL, aspartate transaminase was 58.2 U/l in group I and 62.6 U/l in group II, alanine transaminase in group I was 142.4 U/l in group I and 128.2 U/l in group II, alkaline phosphatase was 284.2 U/l in group I and 302.4 U/l in group II and γ-glutamyltranspeptidase in group I was 98.2 U/l and 118.4 U// in group II. The difference was non- significant (P> 0.05). The mean glutathione level in group I was 0.6 and in group II was 0.4 and which increased to 1.4 in group I and 1.2 in group II after 3 months. The difference within the group found to be significant (P< 0.05). Conclusion: Authors found that there was reduction in alanine transaminase, glutathione and gamma-glutamyltranspeptidase level. Antioxidant therapy with glutathione may reduce the pathological oxidative stress in the liver in NASH, preventing the progression from NAFLD to NASH cases.
Highlights
The presence of a significant (>5% of hepatocytes) fat accumulation in the liver, in the absence of an “unsafe” quantity of alcohol consumption and any other cause of liver diseases, is a potentially pathological condition that is defined as nonalcoholic fatty liver disease (NAFLD).Non-alcoholic fatty liver disease (NAFLD) is a range of hepatic disorders associated with fatty deposits in liver, which occur in the absence of alcohol consumption or alcohol abuse
[1] The progression from steatosis into cirrhosis of the liver due to inflammation and fibrosis results in irreversible damage to the liver. This condition is called nonalcoholic steatohepatitis (NASH)—a term first introduced by Ludwig et al in clinical subjects with no history of alcohol consumption or abuse. [2]
[4] It has been reported that levels of GGT in FL patients may compensate for mild oxidative stress by repressing 8-OHdG levels and preventing progression to NASH; oxidative stress leads to increased levels of 8-OHdG and the development of NASH
Summary
The presence of a significant (>5% of hepatocytes) fat accumulation in the liver, in the absence of an “unsafe” quantity of alcohol consumption and any other cause of liver diseases, is a potentially pathological condition that is defined as nonalcoholic fatty liver disease (NAFLD). Non-alcoholic fatty liver disease (NAFLD) is a range of hepatic disorders associated with fatty deposits in liver, which occur in the absence of alcohol consumption or alcohol abuse. [1] The progression from steatosis into cirrhosis of the liver due to inflammation and fibrosis results in irreversible damage to the liver. This condition is called nonalcoholic steatohepatitis (NASH)—a term first introduced by Ludwig et al in clinical subjects with no history of alcohol consumption or abuse. [5] The present study assessed glutathione level in non-alcoholic fatty liver disease patients It may contribute to clinical progression from simple FL to NASH. [5] The present study assessed glutathione level in non-alcoholic fatty liver disease patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
