Assessment of early renal allograft dysfunction with blood oxygenation level-dependent MRI and diffusion-weighted imaging

Abstract

PurposeTo investigate blood oxygenation level-dependent (BOLD) MRI and diffusion-weighted imaging (DWI) at 3T for assessment of early renal allograft dysfunction. Materials and methods34 patients with a renal allograft (early dysfunction, 24; normal, 10) were prospectively enrolled. BOLD MRI and DWI were performed at 3T. R2* and apparent diffusion coefficient (ADC) values were measured in cortex and medulla of the allografts. Correlation between R2* or ADC values and estimated glomerular filtration rate (eGFR) was investigated. R2* or ADC values were compared among acute rejection (AR), acute tubular necrosis (ATN) and normal function. ResultsIn all renal allografts, cortical or medullary R2* and ADC values were moderately correlated with eGFR (P<0.05). Early dysfunction group showed lower R2* and ADC values than normal function group (P<0.05). AR or ATN had lower R2* values than normal allografts (P<0.05), and ARs had lower cortical ADC values than normal allografts (P<0.05). No significant difference of R2* or ADC values was found between AR and ATN (P>0.05). ConclusionBOLD MRI and DWI at 3T may demonstrate early functional state of renal allografts, but may be limited in characterizing a cause of early renal allograft dysfunction. Further studies are needed.