ASSESSMENT OF COGNITIVE DISORDERS AND BASIC CHARACTERISTICS OF ARTERIAL HYPERTENSION IN NON-COMPLICATED PATIENTS: PP.4.158

Abstract

Objective: Arterial hypertension (AH) is the most prevalent disease among all cardiovascular disorders in majority of developed countries. AH is basic cause of end-organ damage (EOD), such as chronic cerebral ischemia which correlates to cognitive disorders (CD) and dementia. By now there are noticeable few issues dedicated to research of CD in non-complicated AH patients. The aim of present research was study of correlation of CD to indices of basic features in non-complicated AH patients. Design and Method: 74 patients with AH 1 – 2 degree, without stroke and myocardial infarction (mean age 57,4 ± 5,9; 33 male, 41 female) have undergone detailed neuropsychological testing (NT) and estomated qualitatively. 68,9% of them (51/74) had hypertension crisis (HC) in past history. They also have undergone ABPM and echocardiography (echoCG). In a research of ABPM setting were estimated mean systolic and diastolic BP (SBP and DBP) in daytime (7.00 a.m. – 11.00 p.m.) and at night (11.00 p.m. – 7.00 a.m.) and variation of them. Using echoCG and data of growth and weight had been estimated left ventricle mass index (LVMI). Results: Different signs of CD were discovered in all non-complicated patients with AH. Severity level of CD (mainly memory) correlated with: HC in past history (31% (16/51) and 13% (3/23) respectively) (p < 0,01; r = 0,22); increased LVMI (77% (32/44) and 57% (17/30) respectively) (p < 0,01; r = 0,21); increased variation of BP at night (57% (8/14) and 25% (15/60) respectively) (p = 0,03; r = 0,27). There was no correlation between severity of CD and AH degree, mean SBP and DBP both at daytime and at night or continuance of AH according to past history. Conclusions: Present research indicates that different signs of hypertension encephalopathy were discovered in all patients despite of that they had non-complicated AH. Severity of CD correlates to signs of instability course of AH (HC in present history, increased variation of BP (at night)) and to LVH. It had not been found correlation between severity of CD and AH degree.