Assessment of coagulation profiles among sudanese psychiatric patients under antipsychotic drugs attending Hassan Allob Mental Hospital, Gezira State, Sudan (2020)

Abstract

Background: Psychiatric disorder is a mental illness diagnosed by a mental health professional that greatly disorders thinking. A psychotropic drug is a chemical substance that crosses the blood brain barrier (BBB) and acts primarily upon the central nervous system (CNS), where it affects brain function, resulting in change in perception, mood, consciousness, cognition, and behavior. It causes changes in platelet function, plasma coagulation, or fibrinolysis seemed more likely to be responsible for the increase in thrombotic events. Objectives: The aim of this study was to assess the coagulation profiles [Prothrombin Time (PT), International Normalize Ratio (INR), Activated Partial Thromboplastin Time (APTT)] in psychiatric patients under antipsychotic drug administration. Methodology: This is a case-control hospital-based study carried out in Hassan Allob Mental Hospital, Gezira State, Sudan from January to September 2020. A total of 50 psychiatric patients under antipsychotic drug administration as cases (35.52 ± 11.64 years) and 50 normal healthy individuals as controls (32.68 ± 4.85 years) participated in this study. Two ml of venous blood samples were collected from all participants in trisodium citrate container. Coagulation profiles (PT, INR, and APTT) were measured using a Coatron M4 coagulometer. SPSS computer program (v 22.0) was used for data analysis.