Assessment of clinical symptoms and pathological effects of degenerative arthritis in rats

Abstract

Degenerative arthritis, particularly affecting the knee joint, is a prevalent condition in Taiwan. While milder cases may only result in slight discomfort during walking, severe cases can lead to significant mobility issues and even loss of basic movement capabilities. Unfortunately, once articular cartilage is lost due to degenerative arthritis, it cannot be regenerated. Currently, the severity of knee joint degeneration is classified into primary, intermediate, and severe stages, which guides the selection of treatment options. These treatments range from non-surgical interventions to surgical procedures. Given the significance of preventing knee joint degeneration, researchers have been exploring various methods. One such approach involves establishing animal models to mimic degenerative arthritis conditions in humans. In this study, researchers utilized anterior cruciate ligament transection (ACLT) combined with medial meniscectomy (MMx) surgery to create a rat model of degenerative arthritis. The successful establishment of this model provides a valuable tool and assessment of clinical symptoms and pathological effects of degenerative arthritis in rats for studying potential drugs and designing therapeutic strategies for degenerative arthritis. By leveraging this rat model, researchers can investigate the efficacy of different pharmaceutical interventions and therapeutic approaches. This could ultimately lead to the development of novel treatments for degenerative arthritis, benefiting individuals suffering from this debilitating condition.