ASSESSMENT OF CLINICAL PROFILE OF CELIAC DISEASE AMONG CHILDREN AT TERTIARY CARE HOSPITAL

Abstract

Background: Celiac disease is reported to be the most common genetic and food related intolerance, globally. Celiac disease is an autoimmune disease that reported among genetically susceptible individuals. The autoimmune process is reported to be triggered by a well-identified associated environmental factor known as gluten and its related prolamins which are present in wheat, barley and rye.
 Material & Methods: The present prospective study was conducted at department of pediatrics of our tertiary care hospital. The study was an observational study on 30 self-reported patients during a period of one year from January 2017 to December 2017. Patients without any exclusion criteria of sex, religion and socioeconomic status were enrolled by simple random sampling.
 Results: In the present study, on the basis of clinical symptoms we found that in the age group of less than 5 years 75% had diarrhea, 87.5% had abdominal distension, 87.5% had abdominal pain, 75% had anorexia. In the age group of 5-10 years 50% had diarrhea, 66.6% had abdominal distension, 58.3% had abdominal pain, 66.6% had anorexia and 16.6% had constipation. In the age group of more than 10 years 70% had diarrhea, 60% had abdominal distension, 50% had abdominal pain, 40% had anorexia and 20% had constipation.
 Conclusion: We concluded from the present study that most common clinical symptom among children was diarrhea followed by abdominal distention, pain in abdomen, anorexia, constipation, pallor,edema, vitamin deficiencies and mouth ulcers.
 Keywords: Celiac disease, IgA-anti tissue transglutaminase antibodies, Screening.