ASSESSMENT OF CHANGES IN THE LIPID COMPOSITION OF BLOOD PLASMA AND ERYTHROCYTE MEMBRANES IN STUDENTS UNDER STUDY LOAD AND THEIR PREVENTION

Abstract

Introduction. The content of low and high-density lipoproteins, the level of total cholesterol, and the fatty acids composition of blood plasma and erythrocyte membranes were studied in first-year university students. The prevention of stress disorders was carried out with the functional food product “Biolad-Kalina” marmalade (TU 9128-152-02067936-2006) contained 100 mg of a complex of polyphenolic compounds per 100 g of the product, accounting for a therapeutic dose for polyphenol preparations. Material and methods. A group of 10 male students aged 18-20 years studying in the 1st year of full-time study (2nd semester after admission to the university) was examined. The 1st group (control) included 20 healthy male donors; in the 2nd group - 10 male students before a biochemical blood test, the 3rd group - 10 male students of the 2nd group, after a biochemical blood test, invited to take daily for 6 weeks in the morning, 100 g of marmalade “Biolad-Kalina”. Results. The effect of the study load (stress) was shown to be accompanied by the increase in low-density lipoproteins in plasma, the concentration of total cholesterol, total lipids and decrease in the content of total phospholipids, which is typical for dyslipidemia. In blood plasma and erythrocyte membranes, there was an increase in the content of saturated fatty acids (myristic, palmitic) and a decrease in the amount of polyunsaturated fatty acids of n-6 (arachidonic) and n-3 (eicosapentaenoic, docosahexaenoic) families, which causes changes in the physical and chemical properties of erythrocyte membranes, permeability, and lability. Changes in the ratio of fatty acids in the lipid pattern of erythrocyte membranes indicate the presence of destructive processes under the influence of stress. A prophylactic effect of the functional food product of marmalade “Biolad-Kalina” on the studied biochemical indices has been estimated. There was shown its effectiveness in the restoration of lipid metabolism in blood and erythrocyte membranes due to presence in it of a wide range of polyphenolic compounds.