Assessment of cardiovascular dysfunction in Egyptian women with diminished ovarian reserve: A single-center study

Abstract

BackgroundMenopause is widely regarded as associated with cardiovascular disease (CVD) risk. One of the hormones which play a crucial role in preserving the ovarian reserve, is Anti-Müllerian hormone (AMH). This study investigates any relation between AMH and markers of CVD risk such as total cholesterol (TC) triglyceride (TG), low & high-density lipoproteins (LDL and HDL), fasting blood sugar (FBS) and endocan in Egyptian women with low ovarian reserve and to determine their cutoff values as predictors of low AMH. Methods and resultsNinety women with diminished ovarian reserve (DOR) and ninety age-matched women who had normal ovarian reserve (NOR) were included in the study. AMH level and Markers of CVD risk such as total cholesterol (TC) triglyceride (TG), low & high-density lipoproteins (LDL and HDL) and fasting blood sugar (FBS) were estimated. Endocan gene expression (mRNA) was assessed using real-time quantitative reverse transcription-polymerase chain reaction (RT–qPCR). Among the low AMH level group, there were negative correlations between AMH level and treatment duration (p = 0.029) and endocan level (p = 0.01). Contrarily, the AMH level positively correlates with the HDL level (p < 0.001). TG[Cutoff value ≥127.5 mg/dL, p = 0.01], LDL [Cutoff value ≥112.5 mg/dL, p = 0.009], HDL [Cutoff value ≤49.5 mg/dL, p = 0.021], TC/HDL ratio [Cutoff value ≥3.85,p = 0.001], LDL/HDL ratio[Cutoff value ≥2.35, p = 0.007] were found to be predictors of low AMH levels. ConclusionsLow and very low AMH levels in young Egyptian women with DOR may be linked to CVD risk markers.