Abstract
This study was aimed at evaluating antibacterial, cytotoxic, anthelmintic and anti-hyperglycemic activity of aerial part of Cirsium arvense . Antibacterial activity was determined by disc diffusion method at the concentration of 200, 250 and 500 µg/disc. Cytotoxic and anthelmintic activity was carried out according to Meyer and Gade method with slight modification respectively. The anti-hyperglycemic activity was determined by the method followed by Djilani. The extract showed dose dependent antibacterial activity against the experimental bacterial strains except Staphylococcus epidermidi , Streptococcus agalactiae and Enterococcus faecalis . In brine shrimp lethality bioassay, it showed LC 50 at 51 µg/ml that is comparable to that of standard drug, vincristine sulphate (LC 50 0.44 µg/ml). Also it showed dose dependent anthelmintic activity. It did not show anti-hyperglycemic activity. Our findings provide evidence that potential bioactive compounds are responsible for biological activities and further studies are required to isolate these compounds.
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