ASSESSMENT OF ASSOCIATIONS BETWEEN CHRONIC KIDNEY DISEASE: GLOMERULONEPHRITIS WITH NEPHROTIC SYNDROME AND BLOOD GROUPS OF AB0 AND RHESUS SYSTEMS

Abstract

The objective of the research was to evaluate the risk of the development of chronic kidney disease: glomerulonephritis with nephrotic syndrome by antigens of blood groups of AB0 and Rhesus (Rh) systems.
 Material and methods. We examined 119 patients (76 men and 43 women) with chronic kidney disease: primary glomerulonephritis with nephrotic syndrome. The mean age of the patients was 39.65±14.16 years. The patients underwent a puncture biopsy of the kidney to verify the morphological form of the disease. A survey of 1428 healthy individuals was conducted to determine the populational distribution of blood groups phenotypes of AB0 and Rh systems.
 Results. Greater probability of the development of chronic kidney disease: glomerulonephritis with nephrotic syndrome was observed in carriers of 0 Rh+ and AB Rh+ antigens. The fact was interesting that carriers of phenotype 0 Rh– were registered much less of ten in patients than in healthy individuals. This may indicate some resistance to the disease in such individuals. Greater predisposition to the development of chronic kidney disease: glomerulonephritis with nephrotic syndrome was observed in Rh-positive women with blood groups0 (χ2=6.98; р=0.008) and АВ (φ=2.32; р=0.010). The chance of the studied pathology development in Rh-positive women versus Rh-negative was in 2.19 times higher than the same ratio in men. The highest chance to contract the pathology was in Rh-positive women with groups AB and 0 versus B, in 4.49 and 4.34 times more than men, respectively.
 Conclusions. Men with phenotypes A Rh– and B Rh– versus 0 Rh–, women with phenotypes AB Rh+ and 0 Rh+ versus A Rh+ and B Rh+ have the highest risk to contract the disease. Individuals of both genders with groups 0 Rh–and B Rh+ may be resistant to the development of the disease.