Abstract
Objective: The present study is mainly focused on the antigenotoxicity and antioxidant potential of the fruit extract of an important dye yielding plant Terminalia paniculata Roth.
 Methods: Genoprotective activity of the fruit extract was studied by Allium cepa root tip assay. Three modes of treatment were used to perform the antigenotoxicity, that is, pre-treatment, post-treatment, and simultaneous treatment. For the study of antioxidant potential, four different assays were performed.
 Results: Antigenotoxicity studies revealed the protective role of the extract in chromosomal aberrations induced by 2% hydrogen peroxide (H2O2) on A. cepa root tip meristem. The fruit extract showed a significant modulatory effect by means of an inhibition percentage and also it showed a characteristic reversing of chromosomal aberrations induced by H2O2. While in the case of antioxidant activity, the plant extract showed an appreciable antioxidant potential. Four different assays were used to determine the antioxidant potential of T. paniculata. Of these 2,2-diphenyl-1-picryl-hydrazyl-hydrate radical scavenging activity revealed almost equal effect to that of the standard.
 Conclusions: In the present investigation, it has been found that the important dye yielding plant T. paniculata has a significant role in various commercial industries such as food, cosmetics, clothes, and pharmaceutics due to its efficient protective role.
Highlights
Natural products have been of immense importance to humans from ancient times
In the present investigation, it has been found that the important dye yielding plant T. paniculata has a significant role in various commercial industries such as food, cosmetics, clothes, and pharmaceutics due to its efficient protective role
Antigenotoxicity The present is study mainly focused on the protective effect of T. paniculata fruit extract on H2O2-induced oxidative damage
Summary
Natural products have been of immense importance to humans from ancient times. The main sources among them are the plants, without them the mankind is worthless. Terminalia paniculata, an arborescent tree which seems to be used as timber and shelter by our ancestors, is gaining attention toward pharmaceutical products nowadays. Natural dyes have a massive utility in textile, drug, and cosmetic industries as a coloring agent. It is widely used in foodstuff coloring, due to their negligible toxicity. Instead of synthetic colorants, natural ones can promote a perfect and healthy life. T. paniculata is an important dye yielding plant belonging to Combretaceae. Its fruits are used as the major source of the dye
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