Abstract
Natural occurring phenolic compounds play an important role in cancer prevention and shows antimitotic activity. Number of active constituents like phenolic acid, curcuminoids, coumarine, ligans, quinones, etc. is showing antimitotic activity of Momordica dioica. The present work is on phytochemical investigation and examines antimitotic activity of aqueous extract of fruits Momordica dioica at concentration of 15 mg/ml on Allium cepa root meristamatic cells. The fruits are air dried and extracted with solvents like water by maceration method. The evaluation of antimitotic activity is done by using Allium cepa root meristamatic cells parameters where and methotrexate was used as a standard drugs. In Allium assay, aqueous extract of fruits of Momordica diocia(15 mg/ml) and methotrexate act against cells of allium roots and lesser the growth of root and mitotic index when compared with distilled water as control group. The result indicated that cytotoxic property is due to presence of phenolic, alkaloids and flavonoids compounds in 15 mg/ml concentration of aqueous extract of Momordica diocia fruits extract. On the basis of result, we concluded that, 15 mg/ml concentration of Momordica dioica fruits shows good antimitotic activity on the Allium cepa root tip assay.
Highlights
In today’s world, people are suffering from various fatal diseases
The present work is on phytochemical investigation and examines antimitotic activity of aqueous extract of fruits Momordica dioica at concentration of 15 mg/ml on Allium cepa root meristamatic cells
The evaluation of antimitotic activity is done by using Allium cepa root meristamatic cells parameters where and methotrexate was used as a standard drugs
Summary
In today’s world, people are suffering from various fatal diseases. Cancer is one of that disease and second leading cause of death in the world. (Cragg and Newman, 2005) a days, various new anticancer agents are isolated from the natural sources of drugs. (Lee, 2010; Li and Vederas, 2009) The active constituent which is isolated from plants play a vital role in treatment of various diseases and gives special attention such herbal based plants due to its pharmacological activities. The fruit of 10 mg/ml concentration of aqueous extract of Momordica dioica shows good antimitotic activity. (Patil, et al, 2018) From the dichloromethane extract of Momordica dioica roots, five active constituents are isolated which gives good anti-cancer activity on cancerous cell like L1210. (Luo- L, et al, 1998) Based on review of literature that no work has to be done on antimitotic activity at concentration of 15 mg/ml of aqueous extracts of fruits of Momordica diocia. The 15 mg/ ml concentration of aqueous extracts of fruits Momordica diocia was taken because to see the effect of fruits at 15 mg/ ml concentration
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