Abstract
Parametric models are used to investigate the time of leukemia latency in patients treated for Hodgkin's disease. A model of induced carcinogenesis provides a stable projection of the leukemia risk for times beyond the follow-up period. The model is applied to data collected in the International Data Base on Hodgkin's Disease. It permits to estimate the contributions of primary and of relapse treatment to the overall risk of induced leukemia. Latency periods appear to be identical after both treatments supporting the concept of induced leukemogenesis.
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