Assessing the Link between Vitamin D Levels and Miscarriage Risk in Women

Abstract

Background: The issue of miscarriage, sometimes known as missed abortion, is a contemporary concern in the field of obstetrics and gynecology. This condition is characterized by a cluster of clinical symptoms, one of which is the inability of the embryo to survive. Through the process of its metabolism of 1.25(OH) vitamin D, vitamin D has a significant role in promoting the reproductive health of women. Aim of the Study: This study aims to investigate the correlation between Vitamin D deficiency and idiopathic miscarriage in women. Materials and Methods: There were 180 miscarriage survivors who took part in this study.; and only forty-three women with idiopathic miscarriage included in this study. They were attended to private clinics in Karbala Province from the period of May-August/ 2024, and their ages range between (17- 43) years. The confident diagnosis was confirmed according to examination by gynaecologists. Results: The female patients with miscarriage were evaluated to exclude all other potential reasons of miscarriage, including age, body mass index, hypertension, endometrial abnormalities, and smoking. Out of 180 women who experienced miscarriage, only 43 were included in the current study. The study assessed infectious agents and other autoimmune disorders in all participating women to eliminate those with Toxoplasma gondii, Rubella, Chlamydia, Herpes (TORCH), and autoimmune diseases. The findings revealed that only 43 women experienced idiopathic miscarriage, and no women exhibited a significant correlation or positive outcomes for any of the aforementioned characteristics. The study revealed a strong association between the trimester of pregnancy and miscarriage among the patients, indicating notable fetal losses In the first and second trimesters, a substantial association was identified; however, no such relationship was evident in the third trimester. The findings indicated that Vitamin D insufficiency was substantially correlated with miscarriage in all women experiencing miscarriage in the research. In conclusion: The role of Vitamin D deficiency significantly affected the losses of pregnancy in women with idiopathic miscarriage.