Assessing the efficacy, safety and utility of 6-month day-and-night automated closed-loop insulin delivery under free-living conditions compared with insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, multicentre, multinational, single-period, randomised, parallel group study protocol

Gianluca Musolino,Steven V Fox ,Louise Denvir,Judy Sibayan,Korey K Hood ,Malgorzata E Wilinska ,Peiyao Cheng,Fiona Campbell,Stuart A Weinzimer ,Nicola Trevelyan,Craig Kollman,Sara Hartnell,Carlo L Acerini ,Janet M Allen ,Martin Tauschmann,Bruce A Buckingham ,Paul Wadwa,Sarah Borgman,Linda A Dimeglio ,Charlotte K Boughton ,Roman Hovorka

doi:10.1136/bmjopen-2018-027856

Assessing the efficacy, safety and utility of 6-month day-and-night automated closed-loop insulin delivery under free-living conditions compared with insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, multicentre, multinational, single-period, randomised, parallel group study protocol

Gianluca Musolino, Steven V Fox + Show 19 more

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Journal: BMJ open	Publication Date: Jun 1, 2019
Citations: 15	License type: open-access

Affiliation: Wellcome/MRC Institute of Metabolic Science, Wellcome Trust, University of Cambridge, University of Southern California, Nottingham University Hospitals NHS Trust, Jaeb Center for Health Research, Stanford University, Leeds Teaching Hospitals NHS Trust, Yale University, Southampton Children's Hospital, Southampton General Hospital, Cambridge University Hospitals NHS Foundation Trust, Medical University of Vienna, University of Colorado Anschutz Medical Campus, Indiana University – Purdue University Indianapolis

#Sensor Glucose Levels #Closed-loop Insulin Delivery #Insulin Pump Therapy In Children #Behavioural Characteristics Of Participants #Curve Of Glucose #Mean Sensor Glucose #Target Glucose Range #Bolus Insulin Dose #Body Mass Index Z-score #Suboptimal Glycaemic Control

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IntroductionClosed-loop systems titrate insulin based on sensor glucose levels, providing novel means to reduce the risk of hypoglycaemia while improving glycaemic control. We will assess effectiveness of 6-month day-and-night closed-loop...

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