Assessing the Antioxidant Potential of Ginger Aqueous Extract on H2O2 Induced Oxidative Stress in Local Rabbits: A Comprehensive Study of Hematological Parameters

Abstract

This research, that was carried out at the Technical Institute in Bakraju/ Sulaimaniyah Technical University, the aim was to investigate the impact of administering 0.5% hydrogen peroxide via drinking water as an oxidative stress inducer, as well as the effect of an antioxidant in the form of an aqueous extract of ginger tubers (at a dosage of 200 mg/kg), on the physiological characteristics of male domestic rabbits. A total of 48 rabbits distributed into four groups, each group consisting of 12 rabbits. The study lasted for 42 days, the groups were: a control group, a group receiving only hydrogen peroxide (0.05%), a group receiving only the ginger extract (200 mg/kg), and a group receiving both hydrogen peroxide (0.05%) and the ginger extract (200 mg/kg). The second group resulted in negative effects on blood indicators, including a decrease in the total number of RBCs, hemoglobin concentration, PCV, and platelets compared to the other groups. These effects were significant at a level of P≤0.05. However, the third group (200 mg/kg) of aqueous ginger tubers extract had a positive effect, improving all the previously mentioned indicators and significantly surpassing the control and second groups at a probability level of P≤0.05. Additionally, the use of the aqueous extract of ginger tubers in conjunction with hydrogen peroxide in the fourth group prevented or minimized the negative effects of oxidative stress caused by hydrogen peroxide on most of the blood indicators mentioned in the study.