Abstract
A synthetic procedure is outlined where upper-level undergraduate organic chemistry students perform a two-week, semimicroscale aza-Baylis–Hillman reaction to generate an allylic sulfonamide product. Students evaluate several green chemistry reaction metrics of industrial importance (process mass intensity (PMI), E factor, and reaction mass efficiency) and specifically learn the pivotal role that PMI plays in improving operational sustainability. Advantages and disadvantages of the various metrics are highlighted within the context of a multicomponent transformation eliciting current research activity.
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