Exploring the untapped catalytic application of a ZnO/CuI/PPy nanocomposite for the green synthesis of biologically active 2,4,5-trisubstituted imidazole scaffolds.

Abstract

This work is focused on designing an innovative, efficient, and reusable heterogeneous ZnO/CuI/PPy nanocomposite via the self-assembly approach where pyrrole is oxidized into polypyrrole (PPy) and pyrrole also behaves as a reductant in the presence of KI. This so-obtained material was characterized by XRD, FTIR, FESEM, EDX, TEM, XPS, and ICP. TEM clearly shows a spherical morphology with the particle size ranging between 18 and 42 nm. The fabricated nanomaterial was tested for one-pot catalytic synthesis of biologically active 2,4,5-trisubstituted imidazoles under solvent-free conditions. The present work includes the benefits of an easy work-up procedure, higher product yield, shorter reaction duration, and no additional additive requirement under green and sustainable conditions. Moreover, the catalyst exhibited reusability for six runs with no considerable reduction in the respective yields and reactivity (confirmed by XRD, SEM, and TEM of the recycled catalyst). The ICP study shows very low leaching of copper (2.08 ppm) and zinc (0.12 ppm) metals. The approach also presented better values of green metrics like the E-factor, process mass intensity, carbon efficiency and reaction mass efficiency.