Assessing Membrane Protein Structural Dynamics within Lipid Nanodiscs

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Membrane protein structure, dynamics, and function have an intimate relationship with the complex and varied cellular lipid membranes they reside in. Lipid nanodisc technologies provide a membrane protein with a soluble lipid bilayer environment – either through direct extraction within their native lipid surround (Figure 1A) or though reconstitution with isolated lipids (Figure 1B) – amenable to a variety of in vitro investigations.