Abstract
Basophils play an important and non-redundant role as inductor and effector cells of the Th2 response, e.g., helminth infection. In addition, they are involved in a broadening range of pathological conditions including systemic lupus erythematosus, eosinophilic oesophagitis and IgG-mediated systemic anaphylaxis. There is a real need to develop robust <i>in vitro</i> techniques to enable study their role in human disease. Basophil histamine release, sulfidoleukotriene synthesis and the flow cytometric basophil activation test are three methods for diagnosing IgE-mediated allergy <i>in vitro</i>. This talk will describe the potential application of these tests in both allergic and non-allergic contexts, as well as outlining challenges in the performance and interpretation of these functional assays.
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