ASSESS INSULIN RESISTANCE VIA HOMA AND QUICKI INDEXES IN PATIENTS WITH END STAGE CHRONIC KIDNEY DISEASE ON CONSERVATIVE TREATMENT

Abstract

Insulin resistance has been recognized as a predictor of cardiovascular mortality in patients with end-stage chronic kidney disease Objective: To assess insulin resistance via HOMA and QUICKI indexes in patients with end – stage CKD on conservative treatment. Materials and Methods: 60 patients, in the end stage chronic kidney disease and treated by conservation treatment at Hue Central Hospital from 06/2014 to 06/2015 and 30 patients as the control group. Study design : a descriptive, and cross-sectional study. Results: the average HOMA and QUICKI indexes are 4.81 ± 4.92 and 0.58 ± 0.14 respectively in the treatment group; 1.45 ± 0.80 and 0.71 ± 0.12 in the control group (p<0.05. The prevalece of insulin resistance in the treatment group, having kidney disorder, is 56.7%, higher than that in control group (23.3%), (p<0.005). The prevalence of high blood pressure, hypercholesterolemia and triglyceridemia is significantly different between ‘insulin-resistant’ group and ‘non insulin-resistant’ group (p<0.05). The frequency of factors causing chronic renal failure, of anemia and proteinuria is not significantly different between ‘insulin-resistant’ group and ‘non insulin-resistant’ group (p>0.05). Conclusions: the prevalence of insulin resistance in treatment group is higher than in the control group. Factors relating to insulin resistance are high blood pressure, cholesterolemia and triglyceridemia Key words: Insulin resistance, the end stage chronic kidney disease, conservation treatment.