Abstract
Background and Aims : Patients with chronic kidney disease often have multiple comorbidities and the high cardiovascular mortality. Dyslipidemia is one of the possible risk factors associated with uremia and an increased risk of cardiovascular disease. The aim of our study was to evaluate the influence of the duration of program hemodialysis and presence of heart failure (HF) in patients with end-stage chronic kidney disease on the pattern of lipid profile.Methods: All patients were divided into groups: I group included 20 patients with end-stage chronic kidney disease (ESCKD) on hemodialysis (duration - 5 years),II group - 20 patients with ESCKD (over 10 years), III group - 16 patients with ESCKD on hemodialysis with HF (over 10 years). Control group – 12 healthy persons. Laboratory blood tests of lipid profile (Triglycerides (TG), Total Cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Very Low Density Lipoprotein (VLDL)), C Reactive Protein (CRP) were analyzed in addition to standard diagnostic program.Results: The pattern of lipid profile is characterized by increased plasma TG (p˂0.05) second and third groups due to elevated VLDL and decreased HDL compared to the control group. There were a significant difference (p˂0.05) in patients of the first and the third groups between of the lipid profile. We observed positive correlation of dyslipidemia with CRP (p˂0.05). Dyslipidemia is associated with uremia.Conclusions: ESCKD patients have increased risk of CVD. A higher prevalence of dyslipidemia is common among patients with ESCKD on the program hemodialysis. HF is associated with lipoprotein abnormalities and cardiovascular mortality. Background and Aims : Patients with chronic kidney disease often have multiple comorbidities and the high cardiovascular mortality. Dyslipidemia is one of the possible risk factors associated with uremia and an increased risk of cardiovascular disease. The aim of our study was to evaluate the influence of the duration of program hemodialysis and presence of heart failure (HF) in patients with end-stage chronic kidney disease on the pattern of lipid profile. Methods: All patients were divided into groups: I group included 20 patients with end-stage chronic kidney disease (ESCKD) on hemodialysis (duration - 5 years),II group - 20 patients with ESCKD (over 10 years), III group - 16 patients with ESCKD on hemodialysis with HF (over 10 years). Control group – 12 healthy persons. Laboratory blood tests of lipid profile (Triglycerides (TG), Total Cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Very Low Density Lipoprotein (VLDL)), C Reactive Protein (CRP) were analyzed in addition to standard diagnostic program. Results: The pattern of lipid profile is characterized by increased plasma TG (p˂0.05) second and third groups due to elevated VLDL and decreased HDL compared to the control group. There were a significant difference (p˂0.05) in patients of the first and the third groups between of the lipid profile. We observed positive correlation of dyslipidemia with CRP (p˂0.05). Dyslipidemia is associated with uremia. Conclusions: ESCKD patients have increased risk of CVD. A higher prevalence of dyslipidemia is common among patients with ESCKD on the program hemodialysis. HF is associated with lipoprotein abnormalities and cardiovascular mortality.
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