Abstract

ASSESMENT OF HEPATOPROTECTIVE ACTIVITY OF ROOTS AND BARKS OF ACHYRANTHES ASPERA IN CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS

Highlights

  • Based on a study, liver is one of the vital organs in human body having a major role for maintaining, regulating homeostasis of the body by metabolizing protein, fat and carbohydrate [1]

  • Our result demonstrated that carbon tetrachloride caused the hepatotoxicity in rats where 1 ml/kg body weight of carbon tetrachloride significantly increased the Serum glutamic pyruvic transaminase (SGPT) and bilirubin level in one day treatment, while 0.25 ml/kg and 0.50 ml/ kg body weight of CCl4 on one day treatment did not have significant effect on SGPT and bilirubin level

  • Various studies indicate that Achyranthus aspera has so many pharmacological effects on rats including hepatoprotective activity on paracetamol and sodium nitrate induced rats on the other hand this study indicates that with the increase of plant extract dose the level of SGPT and bilirubin decreased in a significant rate (Figure 5 and 6) [20,21,22]

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Summary

Introduction

Liver is one of the vital organs in human body having a major role for maintaining, regulating homeostasis of the body by metabolizing protein, fat and carbohydrate [1]. There are more than 100 types of environmental poisons which can cause liver disease. Though a few data were found to identify the toxic effect of CCl4 in human, but current research reviled that this toxin may cause harmful effect on human liver. An enzyme which is known as serum glutamic pyruvic transaminase normally present in liver. This enzyme is released into the blood when any unusual physiological, pathological changes and damaged occur in liver. Serum glutamic oxaloacetate transaminase (SGOT) is another biomarker to identify liver diseases. It is released into the blood when cells that contain it are damaged. Bilirubin is the yellow breakdown product of normal heme catabolism the elevated levels of bilirubin may indicate certain diseases including hepatotoxicity

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