Abstract
Hydroxypropyl cellulose (HPC) is a derivative of cellulose with both water soluble and organic solubility, used as food additive and sieving matrix for DNA separation. Hydroxypropyl Cellulose is partially substituted poly (hydroxypropyl) ether of cellulose. It contains NLT 53.4% and NMT 80.5% of hydroxypropoxy groups, calculated on the dried basis. It may contain ether suitable anticaking agents, and 0.6 percent of silica (SiO2). The average sample result has been determined 67.3% which was conforms to USP/NF specifications for Hydroxypropyl cellulose.
Highlights
The boiling or reaction flask, consisting of a 125-mL conical-bottom boiling flask modified to provide a thermocouple well and an inlet with a 1.0-mm capillary tip for nitrogen and water is fitted with a distillation head that leads to a condenser
The reaction flask is immersed in an oil bath equipped with an electric heater capable of heating the bath at the desired rate and maintaining the temperature at 155°
The distillate is collected in a flask. [NOTE—the tube from the condenser to the flask must be below the surface of the liquid in the flask to ensure the capture of all of the acetic acid formed [Figure 2] [1]
Summary
2.2.1. Reagents • Sodium bicarbonate, NaHCO3 • Potassium iodide. KI • Hydroxypropylcellulose raw materials were supplied by DOW USA Chemical Corporation, F4M premium grade 2.2.2. Solutions • D. I Water • Chromium Trioxide Solution • 0.02N Sodium Hydroxide Volumetric Solution • Sodium bicarbonate • 2N Sulfuric acid Test Solution • Potassium Iodide • 0.02N Sodium Thiosulfate Volumetric Solution • Starch Indicator test solution. • USP Hydroxypropyl Cellulose RS
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