Abstract
<h3>Objective</h3> To investigate the potential contributing effects of metabolic syndrome (MS) on cardiovascular events and mortality in maintenance hemodialysis (MHD) patients. <h3>Methods</h3> According to the diagnostic criteria for MS set by Chinese Diabetes Society, 201 subjects undergoing MHD were assigned into MS group (n = 78) or non-MS group (n = 123), in August 2009. General and laboratory data were collected for cross-sectional analyses, and the participants were followed up for 36 months. Cardiovascular events, cause of death and time were recorded for longitudinal analyses. <h3>Results</h3> Prevalence of MS was 38.8%. Weight, waist circumference, triglyceride, total cholesterol, low density lipoprotein, fasting glucose level, uric acid and high-sensitivity C-reactive protein were significant higher in MS group compared to non-MS group, but duration of dialysis and high-density lipoprotein were lower (<i>P</i> (28/123), 10.6% (13/123), 17.1% (21/123). There was significant difference between patients with and without MS in cumulative incidence of cardiovascular events (x<sup>2</sup> = 7.601, <i>P</i> = 0.006). There was relationship between the number of metabolic syndrome parameters and cardiovascular events (r = 0.236, <i>P</i> = 0.001). Kaplan-Meier curves showed the relationship between two groups did not remained statistically significant in cardiovascular and all-cause mortality. Impaired glycometabolism in 5 parameters of MS was a cardiovascular mortality risk factor in MHD patients. <h3>Conclusions</h3> The prevalence of MS is high in MHD patients. MS is a risk factor of cardiovascular events, but it is not associated with cardiovascular and all-cause 3-year mortality in patients with MHD.
Published Version
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