Abstract
SummaryAsperuloside (ASP) is an iridoid glycoside that is extracted from Eucommia leaves. Eucommia is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metabolic disorders and show that ASP reduces body weight gain, glucose intolerance, and insulin resistance effectively in mice fed with a high-fat diet (HFD). Intestinal dysbiosis is closely linked with metabolic disorders. Our data indicate that ASP achieves these benefits on metabolic homeostasis by reversing HFD-induced gut dysbiosis and by changing gut-derived secondary metabolites and metabolic signaling. Our results indicate that ASP may be used to regulate gut microbiota for the treatment of obesity and type 2 diabetes.
Highlights
Obesity has recently become epidemic, with one in three people being obese or overweight worldwide, and as such poses a major public health problem (Hoyt et al, 2014)
We investigated the impact of ASP on obesity-related metabolic disorders and show that ASP reduces body weight gain, glucose intolerance, and insulin resistance effectively in mice fed with a high-fat diet (HFD)
Our data indicate that ASP achieves these benefits on metabolic homeostasis by reversing HFD-induced gut dysbiosis and by changing gut-derived secondary metabolites and metabolic signaling
Summary
Obesity has recently become epidemic, with one in three people being obese or overweight worldwide, and as such poses a major public health problem (Hoyt et al, 2014). Knowledge about the gut microbiota in health has grown tremendously (Cani and Delzenne, 2009). Recent studies revealed that some bacteria can change metabolic signaling pathways via their secondary metabolites. Parabacteroides have been shown to attenuate obesity and metabolic dysfunctions via the production of succinate and secondary bile acids (Wang et al, 2019). Based on all these evidences, it is clear that change in the gut microbiota and their secondary metabolites are closely linked to the development of metabolic disease
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