Abstract
Marine-derived fungi are a rich source of structurally diverse metabolites. Fungi produce an array of compounds when grown under different cultivation conditions. In the present work, different media were used to cultivate the fungus Aspergillus sp. ZA-01, which was previously studied for the production of bioactive compounds, and three new prenylxanthone derivatives, aspergixanthones I–K (1–3), and four known analogues (4–7) were obtained. The absolute configuration of 1 was assigned by ECD experiment and the Mo2(AcO)4 ICD spectrum of its methanolysis derivative (1a). All the compounds (1–7) were evaluated for their anti-Vibrio activities. Aspergixanthone I (1) showed the strongest anti-Vibrio activity against Vibrio parahemolyticus (MIC = 1.56 μM), Vibrio anguillarum (MIC = 1.56 μM), and Vibrio alginolyticus (MIC = 3.12 μM).
Highlights
Xanthones, usually obtained from many marine-derived fungi, are a class of secondary metabolites containing a polysubstituted 9H-xanthen-9-one skeleton [1]
Prenylxanthones have been mainly isolated from the fungi of the genus
ZA-01, several new cytotoxic 14,15-hydroxylated prenylxanthones, aspergixanthones A–H were obtained from cultures grown in rice solid medium [9]
Summary
Usually obtained from many marine-derived fungi, are a class of secondary metabolites containing a polysubstituted 9H-xanthen-9-one skeleton [1]. They are described as “privileged structures” in the field of modern medicine [2], due to their pronounced pharmacological activities, including antibacterial [3], antifungal [4], cancer chemopreventive [5,6], and cytotoxic activities [7]. Different HPLC-UV profiles of the EtOAc extract were obtained when fermentation of strain ZA-01 was carried out using a shaken. Czapek-Dox this extract ledled to to thethe isolation of of three new prenylxanthone derivatives, aspergixanthones.
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