Abstract
Several studies show that women are potentially more susceptible to developing lung cancer (LC). Specifically, women are more prone to adenocarcinomas, they usually develop the disease younger, are diagnosed at earlier stages, and female non-smokers are at higher risk. On the other hand, no particular cause has been detected for all LC, which suggests the presence of additive synergistic effects among several causes, in conjunction with predisposing and risk factors for LC. In line with this, the hypothesis that oestrogens can play a role in LC carcinogenesis is gaining acceptance, although the mechanism by which oestrogens are involved in this process is not clear. Although, on the whole, this review suggests women are more likely to smoke and so potentially more prone to develop LC, the influence of these differential characteristics regarding survival is controversial.
Highlights
De entre todos los cánceres, es el cáncer de pulmón del citocromo P540S, responsable de la detoxificación (CP) el que posee más aspectos diferenciales según de las formas activas de hidrocarburos aromáticos policíclicos (HAPs)), que está presente en el género
Although, on the whole, this review suggests women are more likely to smoke and so potentially more prone to develop lung cancer (LC), the influence of these differential characteristics regarding survival is controversial
Las diferencias de predominancia en ERα o ERβ en los distintos tejidos, pueden contribuir a explicar la controversia existente sobre los efectos protectores de los estrógenos en ciertos tejidos, en los que suele predominar ERβ (como el pulmón), a la vez que suponen un riesgo para el desarrollo del cáncer en otros tejidos, tejidos relacionados con el sistema reproductor, en los cuales suele predominar ERα (Morani, Warner y Gustafsson, 2008)
Summary
De entre todos los cánceres, es el cáncer de pulmón del citocromo P540S, responsable de la detoxificación (CP) el que posee más aspectos diferenciales según de las formas activas de HAPs), que está presente en el género. Diferentes trabajos muestran que han descrito en mujeres niveles superiores de aductos las mujeres son potencialmente más vulnerables a de HAPs en comparación con los hombres, incluso con desarrollar un CP.
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